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Human Pangenome Reference Consortium

The Human Pangenome Reference Consortium (HPRC) is a project funded by the National Human Genome Research Instititue to sequence and assemble genomes from individuals from diverse populations in order to better represent genomic landscape of diverse human populations.

We Need More Than One Human Reference Genome

No single genome can represent the diversity in the human population. Using a single reference genome creates reference biases, adversely affecting variant discovery, gene–disease association studies and the accuracy of genetic analyses.

The HPRC was started to help migrate common genomic analysis to use a pangenome so diverse populations are better represented.

What are we doing

Sequencing from diverse set of samples with the newest, long read, technologies
Creating and releasing high-quality assemblies and pangenomes
Fostering an ecosystem of assembly and pangenome tools
Embedding a team of scholars to address ethical, legal and social implications (ELSI) of the HPRC’s work



Milestones

Year1
47
47
47

Current Production
100+
100+
Next Round

Completion
350+
350+
Usable Mature