Working Groups

Population Sampling and Representation

Leads participant recruitment, regulatory approvals, and representation in sequencing efforts to reflect the range of human populations in genomic data collection.

Working Group Leads:

Karen Miga, University of California, Santa Cruz
Eimear Kenny, Icahn School of Medicine at Mount Sinai

Technology and Production

Coordinate data production; develop and optimize protocols; engage technology companies and test new technologies.

Working Group Leads:

Karen Miga, University of California, Santa Cruz
Bob Fulton, Washington University

T2T Assembly

Supports the production and quality assessment of complete, high-quality (T2T) genomic references.

Working Group Leads:

Evan Eichler, University of Washington
Karen Miga, University of California, Santa Cruz
Adam Phillippy, National Human Genome Research Institute

Pangenomes

Pangenome framework, construction, tools, and applications.

Working Group Leads:

Ira Hall, Yale University
Heng Li, Dana-Farber Cancer Institute
Benedict Paten, University of California, Santa Cruz

Resource Improvement and Maintenance

Assesses the quality of the pangenome alignment graph to highlight problematic regions and communicate back to relevant stakeholders. Defines and communicates to the public what a stable release of the pangenome reference is. Develops QC system that enables a multi-faceted assessment of the pangenome. Liaises with different stakeholders with respect to resource status, planned future updates, and available support.

Working Group Leads:

Tina Lindsay, Washington University
Valerie Schneider, National Center for Biotechnology Information
Fergal Martin, EMBL-EBI

Resource Sharing and Outreach

Disseminates information about HPRC data and tools, education, and outreach.

Working Group Leads:

Heather Lawson, Washington University

ELSI

Ethical, legal, and social implications.

Working Group Leads:

Bob Cook-Deegan, Arizona State University
Malia Fullerton, University of Washington
Nanibaa’ Garrison, University of Califonia, Los Angeles

International Outreach

Leads activities of the International Human Pangenome Project, including community building and working with GA4GH workstreams.

Working Group Leads:

Heather Lawson, Washington University
Angela Page, GA4GH at Broad Institute of MIT and Harvard

Publication

Publication policies and strategies to maximize the impact of papers.

Working Group Leads:

Benedict Paten, University of California, Santa Cruz
Ting Wang, Washington University